- One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.
One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.
Journal of the American Chemical Society (2014-12-09)
Woon-Yew Siau, Jeffrey W Bode
PMID25482378
ABSTRACT
The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoromethylketones yields α-CF3 morpholines and piperazines.
MATERIALS
Product Number
Brand
Product Description
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity