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Key Documents

SRP6374

Sigma-Aldrich

Galectin-9 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

Ecalectin, Gal-9, LGALS9, Tumor antigen HOM-HD-21

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

liquid

mol wt

18.5 kDa (168 aa, 1-148 aa + His Tag.)

packaging

pkg of 50 μg

concentration

0.5 mg/mL

UniProt accession no.

O00182

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... LGALS9(3965)

General description

Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to β-galactosides and Forssman pentasaccharide. It is strongly overexpressed in Hodgkin′s disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. Recombinant Galectin-9 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM NaCl and 20% glycerol.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yang Wang et al.
PloS one, 11(3), e0152599-e0152599 (2016-03-31)
Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers. However, the clinical impact and the precise mechanism by which this protein
Gaia Nebbia et al.
PloS one, 7(10), e47648-e47648 (2012-11-01)
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in
Rina Nakajima et al.
Journal of dermatological science, 96(3), 134-142 (2019-12-04)
Galectin-9, a member of the galectin family, can promote tumor growth through inducing apoptosis in anti-tumor immune cells via T cell immunoglobulin and mucin domain 3 (TIM-3). On the other hand, galectin-9 also induces tumor cell apoptosis in many malignancies
R Mukherjee et al.
Food & function, 10(1), 33-37 (2019-01-12)
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ
Anthony L Steichen et al.
PloS one, 10(4), e0123573-e0123573 (2015-04-22)
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis. Here we show that Galectin-9, a host endogenous β-galactoside
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