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SML3240

Sigma-Aldrich

CL264

≥98% (HPLC)

Synonym(s):

2-(4-((6-Amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzamido)acetic acid, CL 264, CL-264, N-[4-[[6-Amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]benzoyl]glycine

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About This Item

Empirical Formula (Hill Notation):
C19H23N7O4
CAS Number:
1510712-69-2
Molecular Weight:
413.43
MDL number:
MFCD32671317
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

General description

CL264 is a hydrophilic molecule. CL264,an adenine analog, is a potent and selective toll-like receptor 7 (TLR7) agonist with no TLR8-stimulating potency. This bioactive small molecule belongs to the category of 9-benzyl-8-hydroxyadenine derivatives. It contains a glycine molecule attached to the benzyl group. Studies show that CL264 is capable of activating NF-κB and stimulating the secretion of IFN-α in cells that express TLR7. CL264 is commonly used at a concentration range from 2 ng/mL to 10 μg/mL for stimulating cells in cultures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mediators of inflammation, 2015, 948540-948540 (2016-01-16)
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