SMB00438

Sophoricoside

≥98% (HPLC)

• Synonym(s): 5′,7′-Dihydroxy-4′-glucosyloxyisoflavone, Genistein-4′-O-glucoside
• Empirical Formula (Hill Notation): C₂₁H₂₀O₁₀
• CAS Number: 152-95-4
• Molecular Weight: 432.38
• UNSPSC Code: 12352205
• PubChem Substance ID: 329825016
• NACRES: NA.25

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: OC1=CC(O)=C(C(C(C2=CC=C(O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)C=C2)=CO4)=O)C4=C1
• InChI: 1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-3-1-9(2-4-11)12-8-29-14-6-10(23)5-13(24)16(14)17(12)25/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m0/s1
• InChI key: ISQRJFLLIDGZEP-JDCPMNFLSA-N

Description

General description

Sophoricoside is an isoflavone glycoside found in the fruit of Sophora japonica. It is a structural isomer of genistin.

Biochem/physiol Actions

Sophoricoside (SOP) improves lipopolysaccharides (LPS)-induced acute lung injury (ALI) in mice by activating the adenosine monophosphate-activated protein kinase (AMPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. It also improves contact dermatitis by inhibiting the nuclear factor-kappa B (NF-κB) pathway in B cells in mice model.

Sophoricoside elicits anti-cancer, immunosuppressive, and anti-inflammatory activities. It inhibits proinflammatory cytokine production in human mast cells and has the potential to treat allergic inflammation diseases.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable