R7772
Roscovitine
≥98% (TLC)
Synonym(s):
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
About This Item
Recommended Products
biological source
synthetic (organic)
Assay
≥98% (TLC)
form
powder
mp
106-107 °C
solubility
chloroform: 50 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
SMILES string
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1
InChI
1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChI key
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Gene Information
human ... CDK1(983) , CDK2(1017) , CDK5(1020) , CDK7(1022) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)
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Application
- an inhibitor of p34cdc2/cyclin B kinase to preculture porcine oocytes
- as a supplement in TCM199 medium for in vitro prematuration of cumulus-oocyte complexes (COCs) of adult goats
- in astrocyte conditioned media as an inhibitor of cyclin-dependent kinase 5 (CDK5)
- as a CDK2 inhibitor in culture media to treat hESCs
Biochem/physiol Actions
Features and Benefits
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
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