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D6500

Sigma-Aldrich

2′-Deoxyadenosine 5′-triphosphate disodium salt

≥97%

Synonym(s):

dATP-Na2

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About This Item

Empirical Formula (Hill Notation):
C10H14N5Na2O12P3
CAS Number:
74299-50-6
Molecular Weight:
535.15
EC Number:
277-809-2
MDL number:
MFCD00080335
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24894029
NACRES:
NA.51

biological source

natural (inorganic)

Quality Level

200

Assay

≥97%

form

powder

storage temp.

−20°C

SMILES string

[Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3

InChI

1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1

InChI key

JEKDCIBJADJZSK-LNUHRGGJSA-L

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Application

2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).
2′-Deoxyadenosine 5′-triphosphate disodium salt has been used:
  • for Smac- X-linked inhibitor of apoptosis protein (Smac-XIAP) binding assay.
  • as a component of polymerase chain reaction (PCR) using AM-toxin primers.
  • to determine the affinity constant (Kd) with the transcription termination factor Rho.
  • to determine the activity of poly ADP-ribose polymerase 1 (PAPR-1 ).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
Gemble S, et al.
PLoS Genetics, 11(7), e1005384-e1005384 (2015)
Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
Cheng J, et al.
American Journal of Human Genetics, 89(1), 56-66 (2011)
Michael Trostler et al.
Biochemistry, 48(21), 4633-4641 (2009-04-08)
We used a series of dATP and dGTP analogues to determine how DNA polymerase I from Bacillus stearothermophilus (BF), a prototypical A family polymerase, uses N-1, N(2), N-3, and N(6) of purine dNTPs to differentiate between right and wrong nucleotide
Fadia Haddad et al.
Methods in molecular biology (Clifton, N.J.), 630, 261-270 (2010-03-20)
Reverse transcription (RT) is the synthesis of complementary deoxyribonucleic acids (DNA) from single-stranded ribonucleic acid (RNA) templates. This process is catalyzed by the reverse transcriptase enzyme, which is the replicating enzyme of retroviruses. Reverse transcriptase was discovered in 1970, and
J E Reardon
Biochemistry, 31(18), 4473-4479 (1992-05-12)
Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was almost as efficient a substrate (kcat/Km) as dTTP for the enzyme. In contrast, the
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