A8476
17-(Allylamino)-17-demethoxygeldanamycin
≥98% (HPLC), solid
Synonym(s):
17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin
About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble
methanol: soluble
antibiotic activity spectrum
neoplastics
Mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
SMILES string
CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
InChI
1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
InChI key
AYUNIORJHRXIBJ-TXHRRWQRSA-N
Gene Information
human ... HSP90AA1(3320) , HSP90AB1(3326)
General description
Application
- to study its effects on hippocampal neurons
- to analyze its effects on yes-associated protein (YAP) phosphorylation in adenocarcinoma human alveolar basal epithelial cells and human breast epithelial cells
- to study its effects on lifespan extension and health in Caenorhabditis elegans
Biochem/physiol Actions
Features and Benefits
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
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