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A4330

Sigma-Aldrich

4′-Aminomethyltrioxsalen hydrochloride

Synonym(s):

4′-Aminomethyl-4,5′,8-trimethylpsoralen hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H15NO3 · HCl
CAS Number:
62442-61-9
Molecular Weight:
293.75
MDL number:
MFCD00134837
UNSPSC Code:
12352200
PubChem Substance ID:
24890846
NACRES:
NA.77

form

powder

Quality Level

200

solubility

H2O: 1 mg/mL
DMSO: 2 mg/mL

storage temp.

2-8°C

SMILES string

CC1=CC(=O)Oc2c(C)c3oc(C)c(CN)c3cc12

InChI

1S/C15H15NO3/c1-7-4-13(17)19-14-8(2)15-11(5-10(7)14)12(6-16)9(3)18-15/h4-5H,6,16H2,1-3H3

InChI key

WBIICVGYYRRURR-UHFFFAOYSA-N

Application

4′-Aminomethyltrioxsalen hydrochloride inactivates DNA and RNA viruses, including HIV-1. 4′-Aminomethyltrioxsalen hydrochloride can covalently bind to nucleic acids when irradiated with UV light.

Biochem/physiol Actions

4′-Aminomethyltrioxsalen hydrochloride is used to inactivate DNA and RNA viruses, including HIV-1, by nucleic acid cross-linking followed by UV irradiation.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000371450
0000371450
0000303630
0000180067
0000180068

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W A Saffran et al.
Mutation research, 274(1), 1-9 (1992-06-01)
Photoreaction with psoralen, a DNA-crosslinking reagent, induces mitotic recombination in the yeast Saccharomyces cerevisiae. Psoralen damage-induced recombination was studied with non-replicating plasmids, which transform yeast cells by undergoing recombination events with chromosomal DNA. When plasmid DNA was photoreacted with psoralen
M N Lubaki et al.
AIDS research and human retroviruses, 10(11), 1427-1431 (1994-11-01)
Studies have shown that cytolytic T lymphocyte (CTL) responses may be critical to the clearance of the early viremia in acute HIV-1 infection. It is likely that these cells play an important role in prolonging the asymptomatic phase of the
D J Hei et al.
Transfusion, 39(3), 239-248 (1999-04-16)
Cytokines generated in platelet concentrates (PCs) during storage have been implicated as possible mediators of febrile nonhemolytic transfusion reactions. Two potential methods of white cell inactivation were compared for their ability to reduce cytokine synthesis in pooled random-donor PC aliquots:
J A Grass et al.
Blood, 91(6), 2180-2188 (1998-04-16)
A photochemical treatment (PCT) process using a novel psoralen and long wavelength ultraviolet light (UVA, 320-400 nm) has been developed to inactivate bacteria and viruses in platelet concentrates. This study evaluated the efficacy of PCT for inactivation of leukocytes that
H Du et al.
RNA (New York, N.Y.), 7(1), 133-142 (2001-02-24)
Base pairing between the 5' end of U1 snRNA and the conserved 5' splice site of pre-mRNA is important for commitment complex formation in vitro. However, the biochemical mechanisms by which pre-mRNA is initially recognized by the splicing machinery is
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