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N5535

Sigma-Aldrich

Niacinamide

meets USP testing specifications

Synonym(s):

Nicotinamide, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

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About This Item

Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
Molecular Weight:
122.12
Beilstein:
383619
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.21

Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

Agency

USP/NF
meets USP testing specifications

Assay

98.5-101.5% dry basis

form

crystals

color

white

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

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1 of 4

This Item
A1472B7313SML1370
assay

≥96% (HPLC)

assay

≥90% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: >1 mg/mL

solubility

-

solubility

-

solubility

-

composition

Peptide content, 92% HPLC

composition

-

composition

-

composition

-

General description

Niacinamide, also known as 3-pyridinecarboxamide, is a water soluble vitamin. It is widely present in plants, animal food and cosmetics.[1]

Application

Niacinamide has been used:
  • as a component of islet maturation culture media[2]
  • to induce differentiation of insulin secreting cells[3]
  • to compare its preclinical effectiveness with that of progesterone[4]

Biochem/physiol Actions

Niacinamide is a primary precursor of nicotinamide adenine dinucleotide (NAD+), which is an important coenzyme in adenosine triphosphate (ATP) production. Nicotinamide deficiency is associated with pellagra.[1]
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

302.0 °F - closed cup

Flash Point(C)

150 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function
    Lau H, et al.
    Xenotransplantation (2019)
    Stimulatory Role of Glycated Fetal Bovine Serum Along with Iron on In Vitro Production of Insulin by Differentiated Mouse Embryonic Stem Cells
    Nishigaki I, et al.
    Journal of Health Science, 57(4), 356-361 (2011)
    Role of nicotinamide in DNA damage, mutagenesis, and DNA repair
    Surjana D, et al.
    Journal of Nucleic Acids, 2010 (2010)
    A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat
    Peterson TC, et al.
    Journal of Neurotrauma, 29(18), 2823-2830 (2012)
    Kathrin Schmeisser et al.
    Nature chemical biology, 9(11), 693-700 (2013-10-01)
    Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans lifespan. Sirtuins mandatorily convert NAD(+)

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