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D0720000

Dexamethasone sodium phosphate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-phosphate disodium salt

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About This Item

Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
2392-39-4
Molecular Weight:
516.40
Beilstein:
6473066
EC Number:
219-243-0
MDL number:
MFCD00079105
UNSPSC Code:
41116107
PubChem Substance ID:
329798630
NACRES:
NA.24
Pricing and availability is not currently available.

grade

pharmaceutical primary standard

API family

dexamethasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChI key

PLCQGRYPOISRTQ-FCJDYXGNSA-L

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone sodium phosphate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Parawee Rattanakit et al.
International journal of pharmaceutics, 422(1-2), 254-263 (2011-11-22)
A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through
Andrew M McMillan et al.
BMJ (Clinical research ed.), 344, e3260-e3260 (2012-05-24)
To investigate the effectiveness of ultrasound guided corticosteroid injection in the treatment of plantar fasciitis. Randomised, investigator and participant blinded, placebo controlled trial. University clinic in Melbourne, Australia. 82 people with a clinical and ultrasound diagnosis of plantar fasciitis unrelated
Philip A Bird et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 32(6), 933-936 (2011-07-05)
To measure dexamethasone concentrations in the plasma and perilymph of the human ear after intravenous (IV) and intratympanic (IT) administration and to compare these with previous studies with methylprednisolone. Patients were administered dexamethasone by the IT or IV routes approximately
Jun-yun Xie et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(2), 130-137 (2011-11-25)
Bupleurum chinense DC had hepato-protective, anti-inflammatory, antipyretic, analgesic, and immunomodulatory effect in traditional Chinese medicine. This study was to determine whether the crude polysaccharides isolated from the roots of Bupleurum chinense DC (BCPs) attenuated lipopolysaccharide (LPS)-induced acute lung injury in
Xiaolin Xu et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 249(10), 1503-1510 (2011-05-21)
To assess how safe and effective it is to use menthol as a permeability enhancer in ophthalmic drug delivery systems. In this study, the effect of menthol on permeability of dexamethasone disodium phosphate in the cornea and sclera was investigated
View All Related Papers

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