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C-130

Supelco

Cortisone solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
53-06-5
Molecular Weight:
360.44
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

General description

Cortisone is a corticosteroid produced in the adrenal glands. Cortisone is administered for short term pain relief and to reduce swelling from inflammation. This Certified Spiking Solution® is applicable in LC-MS/MS applications for endocrinology, clinical chemistry and neonatal screening.

Application


  • Measurement of free urinary cortisol and cortisone: A study demonstrated the use of cortisone solutions in a method for the precise measurement of free urinary cortisol and cortisone using liquid chromatography and tandem mass spectrometry, crucial for diagnosing and managing endocrine disorders (Vieira et al., 2005).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cortisone ≥95%

Sigma-Aldrich

C2755

Cortisone

[Cortisone substitution in sepsis. Is less more?].
J Briegel
Der Anaesthesist, 52 Suppl 1, S24-S31 (2004-01-17)
H Pirgă
Oftalmologia (Bucharest, Romania : 1990), 37(2), 154-156 (1993-03-01)
The cortisonical treatment has been more and more used in the last years, with an anti-inflammatory purpose, in ocular and general affections. The most severe ocular complications due to the prolonged treatment are the cortisonic glaucomas and the cortisonic cataract
I Uttner et al.
Der Nervenarzt, 77(6), 647-648 (2005-11-12)
Treatment with high-dose corticosteroids over 3-5 days reduces the duration and severity of relapses in patients with multiple sclerosis. Since the benefit of this treatment appears to be dose-dependent, application of ultrahigh steroid doses becomes important. On the other hand
Stephen G Hillier
The Journal of endocrinology, 195(1), 1-6 (2007-10-04)
The year 1946 was not only the year that the Society for Endocrinology was founded, but also the year that Edward Kendall's compound E (cortisone) was first synthesised by Louis Sarett. By 1948, sufficient quantities of compound E were available
M Malaguarnera et al.
Pharmacotherapy, 17(5), 998-1005 (1997-11-05)
Over the last 30 years many approaches have been adopted to treat chronic hepatitis. We conducted a meta-analysis to assess the efficacy of various types of treatments. We selected 4 studies of cortisone in chronic hepatitis B; 21 trials of
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