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Merck
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Key Documents

T16403

Sigma-Aldrich

2,2′,4,4′-Tetrahydroxybenzophenone

97%

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About This Item

Linear Formula:
[(HO)2C6H3]2CO
CAS Number:
Molecular Weight:
246.22
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

97%

mp

198-200 °C (lit.)

SMILES string

Oc1ccc(c(O)c1)C(=O)c2ccc(O)cc2O

InChI

1S/C13H10O5/c14-7-1-3-9(11(16)5-7)13(18)10-4-2-8(15)6-12(10)17/h1-6,14-17H

InChI key

WXNRYSGJLQFHBR-UHFFFAOYSA-N

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Application


  • Urinary concentrations of bisphenol A, parabens and benzophenone-type ultra violet light filters in relation to sperm DNA fragmentation in young men: A chemical mixtures approach.: This study investigates the relationship between urinary concentrations of various chemicals, including benzophenone-type UV filters like 2,2′,4,4′-Tetrahydroxybenzophenone, and sperm DNA fragmentation. The findings highlight potential reproductive toxicity risks associated with exposure to these compounds (Kiwitt-Cárdenas et al., 2024).

  • Salting-out assisted liquid-liquid extraction combined with LC-MS/MS for the simultaneous determination of seven organic UV filters in environmental water samples: method development and application.: This paper discusses the development of a method for detecting organic UV filters, including 2,2′,4,4′-Tetrahydroxybenzophenone, in environmental water samples. The method offers a reliable way to monitor the presence of these compounds in the environment (Carve et al., 2023).

  • Novel visible-light-active P-g-CN-based α-Bi(2)O(3)/WO(3) ternary photocatalysts with a dual Z-scheme heterostructure for the efficient decomposition of refractory ultraviolet filters and environmental hormones: Benzophenones.: The study presents a new photocatalyst capable of degrading benzophenone-type UV filters, including 2,2′,4,4′-Tetrahydroxybenzophenone, under visible light. This development has significant implications for environmental cleanup technologies (Berekute et al., 2023).

  • Boosting elimination of sunscreen, Tetrahydroxybenzophenone (BP-2), from water using monopersulfate activated by thorny NanoBox of Co@C prepared via the engineered etching strategy: A comparative and mechanistic investigation.: This research explores a novel method for removing 2,2′,4,4′-Tetrahydroxybenzophenone from water using advanced nanotechnology, highlighting its effectiveness and potential for environmental applications (Khiem et al., 2023).

  • The binding mechanism of benzophenone-type UV filters and human serum albumin: The role of site, number, and type of functional group substitutions.: The study examines how benzophenone-type UV filters, including 2,2′,4,4′-Tetrahydroxybenzophenone, interact with human serum albumin, providing insights into their behavior in biological systems and potential health implications (Ma et al., 2023).

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1A

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Victor Kuete et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(6), 528-536 (2013-03-20)
The emergence of drug-resistant cancer cells drastically reduces the efficacy of many antineoplasic agents and, consequently, increases the frequency of therapeutic failure. Benzophenones are known to display many pharmacological properties including cytotoxic activities. The present study was aimed at investigating
Hubertus Jarry et al.
Toxicology, 205(1-2), 87-93 (2004-10-02)
The chemical industry has developed sun protection factor products, which contain a variety of so-called "UV screens", among others, benzophenones (BP). Based on the structure it can be assumed, that the variant BP2 may be a potent estrogenic endocrine disrupter
Christiane Schlecht et al.
Toxicology, 205(1-2), 123-130 (2004-10-02)
The estrogen receptors (ERs) are members of a super family of ligand-activated transcription factors mediating estrogenic responses. A close functional kinship was found for the structurally related estrogen receptor-related receptor1 (ERR1), a constitutively active transcription factor. The aryl hydrocarbon receptor
Christin J Weisbrod et al.
Toxicology and applied pharmacology, 225(3), 255-266 (2007-09-25)
The UV filter benzophenone-2 (BP-2) is largely used in personal care products such as cosmetics and in numerous other materials for UV protection. Like other UV filters, BP-2 has been found to be estrogenic in vitro and in vivo, but
Michael H Hsieh et al.
The Journal of urology, 178(4 Pt 2), 1637-1642 (2007-08-21)
Additives such as benzophenone-2 are commonly used in cosmetic products and food container plastics to filter out ultraviolet light. In pregnant women exposure may result in transplacental transfer of benzophenone-2 to fetuses. Benzophenone-2 is estrogenic in vitro and in the

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