927813

PFPSA-alkyne

≥95%

• Synonym(s): N-(But-3-yn-1-yl)-2,3,4,5,6-pentafluorobenzenesulfonamide
• Empirical Formula (Hill Notation): C₁₀H₆F₅NO₂S
• Molecular Weight: 299.22
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder
• storage temp.: −20°C

Description

Application

PFPSA-alkyne is a probe that can be used to label cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitave applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable