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550019

Sigma-Aldrich

N,N-Dimethyldipropylenetriamine

99%

Synonym(s):

DMAPAPA

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About This Item

Linear Formula:
(CH3)2N(CH2)3NH(CH2)3NH
CAS Number:
10563-29-8
Molecular Weight:
159.27
EC Number:
234-148-4
MDL number:
MFCD00082192
UNSPSC Code:
12352100
PubChem Substance ID:
24879085
NACRES:
NA.22

Assay

99%

refractive index

n20/D 1.4630 (lit.)

bp

220 °C (lit.)

density

0.883 g/mL at 25 °C (lit.)

functional group

amine

SMILES string

CN(C)CCCNCCCN

InChI

1S/C8H21N3/c1-11(2)8-4-7-10-6-3-5-9/h10H,3-9H2,1-2H3

InChI key

OMKZWUPRGQMQJC-UHFFFAOYSA-N

General description

N,N-Dimethyldipropylenetriamine is an aliphatic acyclic amine that is commonly used to develop polymeric system for gene delivery.

Application

N,N-Dimethyldipropylenetriamine (DP) may be used to:
  • Prepare poly(ethylene oxide)-b-poly(3-caprolactone-g-DP) [PEO-b-P(CL-g-DP)], a biodegradable amphiphilic polycationic copolymer.
  • Develop a second generation aminoglycoside 6′-N-acetyltransferase (AAC(6′) inhibitor.
  • Prepare a hydrophilic gemcitabine conjugated cationic copolymer, which can be employed in the treatment pancreatic cancer.

Legal Information

Product of Arkema Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Corr. 1A - Skin Sens. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

210.2 °F - closed cup

Flash Point(C)

99 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCK2360
SHBJ5040
SHBH2431V
SHBG4812V
SHBG4637V

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Anupama Mittal et al.
Biomaterials, 35(25), 7077-7087 (2014-05-20)
Clinical effectiveness of gemcitabine in pancreatic cancer is hindered due to its rapid plasma metabolism and development of chemo-resistance. We have previously delineated the significant role of miRNAs in mediating the growth and proliferation of cancer stem cells (CSCs) which
Feng Gao et al.
Journal of medicinal chemistry, 49(17), 5273-5281 (2006-08-18)
Truncated aminoglycoside-coenzyme A bisubstrate analogues were efficiently prepared using a convergent approach where the amine and the thiol are coupled in one pot with the addition of a linker, without the need for protecting groups. These derivatives were tested for
Xiao-Bing Xiong et al.
Biomaterials, 30(2), 242-253 (2008-10-08)
The RNA interference (RNAi) technology has been successfully used in elucidating mechanisms behind various biological events. However, in the absence of safe and effective carriers for in vivo delivery of small interfering RNAs (siRNAs), application of this technology for therapeutic
[Toxicity of several aliphatic amines].
G I Sidorin et al.
Gigiena truda i professional'nye zabolevaniia, (11)(11), 50-53 (1984-11-01)
J Shen et al.
Biomaterials, 34(18), 4520-4531 (2013-03-23)
The low toxicity and efficient gene delivery of polymeric vectors remain the major barrier to the clinical application of non-viral gene therapy. Here, we present a poly-D, L-succinimide (PSI)-based biodegradable cationic polymer which mimicked the golden standard, branched polyethylenimine (PEI

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