392626

Diethyl (hydroxymethyl)phosphonate

technical grade

• Synonym(s): (Hydroxymethyl)phosphonic acid diethyl ester, Diethyl phosphonomethanol
• Linear Formula: HOCH₂P(O)(OC₂H₅)₂
• CAS Number: 3084-40-0
• Molecular Weight: 168.13
• EC Number: 221-391-6
• MDL number: MFCD00014418
• UNSPSC Code: 12352108
• PubChem Substance ID: 24864471
• NACRES: NA.22

Properties

• grade: technical grade
• form: liquid
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.444 (lit.)
• bp: 124-126 °C/3 mmHg (lit.)
• density: 1.14 g/mL at 25 °C (lit.)
• functional group: hydroxyl; phosphonate
• SMILES string: CCOP(=O)(CO)OCC
• InChI: 1S/C5H13O4P/c1-3-8-10(7,5-6)9-4-2/h6H,3-5H2,1-2H3
• InChI key: RWIGWWBLTJLKMK-UHFFFAOYSA-N

Description

Application

Reactant for synthesis of:

• α And β-dialkoxyphosphoryl isothiocyanate used in antiproliferative studies
• Dendritic polyglycerol anions for L-selectin inhibition
• Phosphonates for anti-HIV-1 activity
• Homo and copolymers of phosphonated norbornenes

Involved in studies of FBPase inhibition by phosphonic acid-containing thaizoles

Reactant for Mitsunobu reactions

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point(F): >752.0 °F - closed cup
• Flash Point(C): > 400 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves