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244929

Sigma-Aldrich

Dichloro(ethylenediamine)platinum(II)

99%

Synonym(s):

Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Platinum ethylenediamine dichloride

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About This Item

Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
14096-51-6
Molecular Weight:
326.08
EC Number:
237-943-4
MDL number:
MFCD00000011
UNSPSC Code:
12161600
PubChem Substance ID:
24854717
NACRES:
NA.22

Quality Level

100

Assay

99%

form

solid

reaction suitability

core: platinum
reagent type: catalyst

SMILES string

Cl[Pt]Cl.NCCN

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

Related Categories

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000227773
0000238172
0000224994
0000224991
0000211037

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A Eastman
Chemico-biological interactions, 61(3), 241-248 (1987-03-01)
Glutathione can modulate the toxicity of a variety of drugs, although its role in modulating toxicity by anticancer platinum drugs is ambivalent. At physiologically relevant concentrations, glutathione can inhibit the reaction between DNA and cis-dichloro(ethylenediamine)platinum(II) (cis-DEP). Glutathione can also react
T J Kelley et al.
Cancer biochemistry biophysics, 13(3), 135-146 (1993-06-01)
Cisplatin (cis-diamminedichloroplatinum(II); cis-DDP) is used as an effective drug for treatment of a variety of cancers, such as carcinomas of bladder, ovarian, and testicular origin. Immunopurified DNA polymerase-alpha from rat prostate tumor PA-3 cells was inhibited (50%) in the presence
E Kimura et al.
Cancer chemotherapy and pharmacology, 32(6), 419-424 (1993-01-01)
Expression of the heat-shock protein HSP-60 is associated with poor survival in patients with ovarian carcinoma. We examined both the nature of the interaction between hyperthermia and cisplatin (DDP) using the human ovarian carcinoma cell line 2008 and the effect
W L Armarego et al.
European journal of biochemistry, 164(2), 403-409 (1987-04-15)
Potassium tetrachloroplatinate (K2PtCl4) inactivates dihydropteridine reductase from human brain in a time-dependent and irreversible manner. The inactivation has been followed by measuring enzyme activity and fluorescence changes. The enzyme is completely protected from inactivation by NADH, the pterin cofactor [quinonoid
B E Bowler et al.
Biochemistry, 25(10), 3031-3038 (1986-05-20)
We report the DNA binding site preferences of the novel molecule AO-Pt, in which the anticancer drug dichloro(ethylenediamine)platinum(II) is linked by a hexamethylene chain to acridine orange. The sequence specificity of platinum binding was mapped by exonuclease III digestion of
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