100013
4,4′-Dimethoxytrityl chloride
95%
Synonym(s):
DMT-Cl
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About This Item
Linear Formula:
C6H5C(C6H4OCH3)2Cl
CAS Number:
Molecular Weight:
338.83
Beilstein:
2471942
EC Number:
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
95%
form
solid
mp
119-123 °C (lit.)
functional group
chloro
phenyl
SMILES string
COc1ccc(cc1)C(Cl)(c2ccccc2)c3ccc(OC)cc3
InChI
1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3
InChI key
JBWYRBLDOOOJEU-UHFFFAOYSA-N
General description
DMT-Cl is commonly used as a protecting group for various functional groups in organic synthesis.
Application
Hydroxyl protecting group for nucleosides and nucleotides.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
8B - Non-combustible corrosive hazardous materials
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Journal of the American Chemical Society, 115, 4985-4985 (1993)
T Tuschl et al.
Biochemistry, 32(43), 11658-11668 (1993-11-02)
The three guanosines of the central core of a hammerhead ribozyme were replaced by 2-aminopurine ribonucleoside, xanthosine, isoguanosine, inosine, and deoxyguanosine. These analogues were incorporated by automated solid-phase synthesis, with the exception of isoguanosine. This was introduced by ligating a
Organoiodinane oxyanions as reagents for the cleavage of a reactive phosphate
Moss RA, et al.
The Journal of Organic Chemistry, 51, 4303-4307 (1986)
Y Ueno et al.
Nucleic acids research, 21(19), 4451-4457 (1993-09-25)
The preparation of a nucleotidyl-peptide having a thymidine-5'-yl-(P-O)-serine phosphodiester bond, [H-Ala-Ser(pTpT)-Phe-OH](24) is described. After condensation between the phosphorylated peptide component and an oligonucleotide component, all protecting groups could be removed under neutral conditions without beta-elimination of the pTpT from the
Thomas F Scott et al.
Clinical neurology and neurosurgery, 127, 86-92 (2014-12-03)
To describe a "new natural history" of multiple sclerosis (MS), characterizing three patterns of progression in Relapsing MS (RMS) patients during the "treatment era," using newly developed definitions. By utilizing our simple model we intend to predict which patients are
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