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G1007617

HPLC Analysis of Atorvastatin and Related Compound E on Kromasil® 5-AmyCoat Chiral

application for HPLC

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About This Item

technique(s)

HPLC: suitable

test parameters

column: Kromasil 5-AmyCoat, 25 cm x 4.6 mm, 5 μm particles (K08670348)
mobile phase: 84:16 hexane: ethanol with 0.1% TFA
flow rate: 1 mL/min
pressure: 1117 psi (77 bar)
column temp.: 25 °C
detector: UV, 254 nm
injection: 20 μL
sample: 50 μg/mL atorva

suitability

application for HPLC

application(s)

pharmaceutical (small molecule)

Analysis Note

Atorvastatin calcium also known as HMG-CoA reductase inhibitors in a class of lipid-lowering medications that reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood and raise “good” cholesterol (high-density lipoprotein, or HDL). The enantiomer of atorvastatin (related compound E) could qualitatively and quantitatively differ in their activities, in pharmacokinetic behavior or pharmacodynamics. The application exhibits baseline resolution under 9 minutes of a racemic mixture of atorvastatin calcium and related compound E on a 5.0 μm Kromasil 5-AmyCoat Chiral.

Legal Information

Kromasil is a registered trademark of EKA Chemicals AB

Analyte

Description
    Atorvastatin related compound E (PHR1872)
    Atorvastatin Calcium, Pharmaceutical Secondary Standard; Certified Reference Material

mobile phase component

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