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Key Documents

WH0255631M7

Sigma-Aldrich

Monoclonal Anti-COL24A1 antibody produced in mouse

clone 1D8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-collagen, type XXIV, alpha 1

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100 μG
€492.00

€492.00

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100 μG
€492.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

€492.00

Please contact Customer Service for Availability

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1D8, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

NM_152890

UniProt accession no.

Q17RW2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL24A1(255631)

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General description

Collagen type XXIV α 1 (COL24A1) is part of the fibril-forming family of collagen molecules and is expressed in bones.

Immunogen

COL24A1 (NP_690850, 1626 a.a. ~ 1714 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
PRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQDGSWHKATFLFHTQEPNQLPVIEVQKLPHLKTERKYYIDSSSVCFL

Biochem/physiol Actions

Collagen type XXIV α 1 (COL24A1) takes part in modulating various processes in the cartilage and bone. It has been linked to head and neck squamous cell carcinoma.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
07173-1D8

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CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts.
Matsuo N
The Journal of Biological Chemistry, 281(9), 5445-5452 (2006)
Kiyoshi Misawa et al.
Molecular and clinical oncology, 2(2), 285-291 (2014-03-22)
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer, affecting ~500,000 individuals worldwide annually. Collagen is the major constituent of the extracellular matrix component in tumors and plays a crucial role in

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