Uvaolis a pentacyclic triterpene compound usually extracted from plant leaves such as Apocynum venetum L., olive leaves (Olea europaea L.), and oregano (Origanum vulgare L.).
Application
Uvaol has been used as retinoic acid receptor-related orphan receptor gamma t (RORγt) inhibitor to study the role of cardiac glycoside reductase 2 (Cgr2) enzyme on its metabolism.
Biochem/physiol Actions
Uvaolexerts pharmacological properties such as antioxidant, anticancer, anti-inflammatory, and wound healing. It also displays vasodilator, hepatoprotective, and antimicrobial effects. Uvaol has inhibitory effects on nitric oxide (NO) release.
Apocynum venetum leaves are used as a kind of phytomedicine and the main ingredient in some traditional Chinese medicine products for the relief of colitis. To understand the bioactive constituents of A. venetum L., we did a phytochemistry study and
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32(17), 1762-1765 (2007-11-13)
To investigate the chemical constituents of Pyrola calliatha. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. Ten compounds were isolated and identified as chimaphilin (1), uvaol(2), ursolic acid (3), 2beta,3beta,23-trihydroxy-12-ene-28-ursolic acid
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 micrograms/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol
Phytochemical investigation of the methanolic extract of Plumeria acutifolia (Apocynaceae) leaves has led to the isolation and identification by spectroscopic means of a new monoterpene alkaloid, (R)-4'-((S)-1-hydroxyethyl)-5,6-dihydro-5' H-spiro[cyclopenta[C]pyridine-7,2'-furan)-5'-one, for which the name plumerianine was adopted, the iridoid 15-demethylplumeride, and three
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(3), 375-378 (2011-08-10)
To study the chemical constituents of Coleus forskohlii. Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F. Compounds were identified and elucidated by spectral and chemical methods. Seven compounds were obtained from ethyl acetate extract
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