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SRP6426

Sigma-Aldrich

E-Cadherin/ECAD/Cadherin-1/CD324 Protein human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym(s):

Arc-1, CDH1, LCAM, UVO

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

tag

6-His tagged (C-terminus)

sterility

sterile

Assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

calculated mol wt 67 kDa
observed mol wt 67 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 23 is the predicted N-terminal.)

packaging

pkg of 25 μg

UniProt accession no.

P12830

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CDH1(999)

General description

Cadherin-1 (CDH1) is a transmembrane protein, which is mainly involved in cell adhesion in normal epithelia. The associated gene is mapped to human chromosome 16q22.1.

Biochem/physiol Actions

Cadherin-1 (CDH1) stabilizes the cell adhesion in normal cells and also helps in signaling via association with β catenin. Mutations in the CDH1 gene are linked with oral clefts in the Thai population. CDH1 works as a tumor suppressor in various cancers. Low expression of CDH1 increases cellular invasive and metastatic potential. For instance, low expression of this gene is associated with poor survival of patients with esophageal cancer.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping.
Huntsman DG and Caldas C
Cytogenetics and Cell Genetics, 83, 82-82 (1998)
Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.
Ishiguro H, et al.
World Journal of Surgical Oncology, 14, 240-240 (2016)
miR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/?-Catenin and Notch-1/Akt Signaling Pathways.
Song H, et al.
International Journal of Molecular Sciences, 17, E1799-E1799 (2016)
Variants of the CDH1 (E-Cadherin) Gene Associated with Oral Clefts in the Thai Population.
Ittiwut R, et al.
Genetic Testing and Molecular Biomarkers, 20, 406-406 (2016)
Dapeng Sun et al.
PloS one, 17(9), e0274919-e0274919 (2022-09-23)
Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. Our results showed that miR-206 mimics suppressed CALR

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