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SML3508

Sigma-Aldrich

Intepirdine

≥98% (HPLC)

Synonym(s):

3-(Phenylsulfonyl)-8-(1-piperazinyl)quinoline, 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline, GSK 742457, RVT 101, SB-742457

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5 MG
€76.40
25 MG
€308.00

€76.40

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5 MG
€76.40
25 MG
€308.00

About This Item

Empirical Formula (Hill Notation):
C19H19N3O2S
CAS Number:
607742-69-8
Molecular Weight:
353.44
MDL number:
MFCD12828872
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

€76.40

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CC=C1)(C2=CC3=C(N=C2)C(N4CCNCC4)=CC=C3)=O

InChI key

JJZFWROHYSMCMU-UHFFFAOYSA-N

Biochem/physiol Actions

Brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist
Intepirdine (SB-742457) is a brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist that potentiate cognitive and the behavioral abnormalities of AD in laboratory set up. Intepirdine has failed to demonstrate statistically significant impact on cognition or dementia in phase III trials. Intepirdine promotes satiety.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801
Brain Research, 1722, 146375-146375 (2019)
The 5-HT?C receptor agonist, lorcaserin, and the 5-HT? receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour
Psychopharmacology, 233(3), 417-424 (2016)
5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
Neurotherapeutics, 5(3), 458-469 (2008)

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