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SML0931

Sigma-Aldrich

Carbimazole

≥98% (HPLC)

Synonym(s):

1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline, 1-Methyl-3-carbethoxy-2-thioglyoxalone, 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic acid ethyl ester, Athyromazole, Carbethoxymethimazole, Carbimazol, Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C7H10N2O2S
CAS Number:
22232-54-8
Molecular Weight:
186.23
EC Number:
244-854-4
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3

InChI key

CFOYWRHIYXMDOT-UHFFFAOYSA-N

Biochem/physiol Actions

Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase. Carbimazole is used to treat hyperthyroidism. Also, carbimazole induces phosphorylation of eukaryotic elongation factor eEF2.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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[59 year-old man with skin and eye alterations and diabetes mellitus].
N Ewald et al.
Deutsche medizinische Wochenschrift (1946), 137(19), 997-998 (2012-05-03)
Maternal thyrotoxicosis and fetal goitre requiring in utero therapy for hypothyroidism and subsequent neonatal therapy for hyperthyroidism.
Katie Groom et al.
Journal of paediatrics and child health, 49(1), E102-E103 (2013-01-17)
Kirsten Campbell et al.
Australian family physician, 41(8), 564-572 (2012-11-13)
Thyrotoxicosis is common in the Australian community and is frequently encountered in general practice. Graves disease, toxic multinodular goitre, toxic adenoma and thyroiditis account for most presentations of thyrotoxicosis. This article outlines the clinical presentation and evaluation of a patient
Matteo Cassina et al.
Birth defects research. Part A, Clinical and molecular teratology, 94(8), 612-619 (2012-04-19)
Clinical hyperthyroidism has been associated with an increased risk of maternal, fetal, and neonatal complications. The available antithyroid drugs are methimazole/carbimazole and propylthiouracil. Several case reports and some epidemiologic studies suggest that methimazole/carbimazole exposure during the first trimester of pregnancy
E T Bell et al.
The Journal of small animal practice, 53(11), 661-663 (2012-09-11)
A 12-year-old female neutered ragdoll crossbred cat was presented for investigation of generalised weakness and regurgitation. The cat was being treated with transdermal methimazole for hyper-thyroidism, which had been diagnosed 10 weeks previously. An acetylcholine receptor antibody titre was consistent
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