Skip to Content
Merck
All Photos(1)

Documents

SML0757

Sigma-Aldrich

WS6

≥98% (HPLC)

Synonym(s):

4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide, WS-6

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C29H31F3N6O3
CAS Number:
1421227-53-3
Molecular Weight:
568.59
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)

InChI key

FTODTDQFHDJWIQ-UHFFFAOYSA-N

Biochem/physiol Actions

WS6 is an inducer of β cell proliferation, thought to act primarily through modulating the activities of the IKB kinase pathway and ErbB3-binding protein 1 (EBP1) also known as proliferation-associated protein 2G4 (PA2G4), an RNA-binding protein that is involved in growth regulation and inhibition.
WS6 is an inducer of β cell proliferation, thought to act primarily through modulating the activities of the IKB kinase pathway and ErbB3-binding protein 1 (EBP1). WS6 is also known to stimulate human ɑ cell proliferation. WS6 does not affect β cell differentiation, as no alteration in the number of insulin producing β cells is observed

Features and Benefits

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability.
Boerner B P, et al.
Endocrine Journal, 62(4), 379-386 (2015)
Manuel Garcia-Moreno et al.
Molecular cell, 74(1), 196-211 (2019-02-26)
The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the development of RNA-interactome capture (RIC). However, it remained unknown if the complement of RBPs changes in response to environmental perturbations and whether these rearrangements are important. To answer these

Articles

EGFR

Our company offers many products related to EGFR for your research needs.

EGFR

Our company offers many products related to EGFR for your research needs.

EGFR

Our company offers many products related to EGFR for your research needs.

EGFR

Our company offers many products related to EGFR for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service