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SML0745

Sigma-Aldrich

NS6180

≥98% (HPLC)

Synonym(s):

4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

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About This Item

Empirical Formula (Hill Notation):
C16H12F3NOS
CAS Number:
353262-04-1
Molecular Weight:
323.33
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2

InChI key

ZUIJXKLTUFCDGO-UHFFFAOYSA-N

Biochem/physiol Actions

NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1) The IC50 of NS6180 against cloned human KCa3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Potassium Channels

We offer many products related to potassium channels for your research needs.

Potassium Channels

We offer many products related to potassium channels for your research needs.

Potassium Channels

We offer many products related to potassium channels for your research needs.

Potassium Channels

We offer many products related to potassium channels for your research needs.

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