SML0678

Pyridostatin trifluoroacetate salt

≥98% (HPLC)

• Synonym(s): 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide trifluoroacetate salt, RR82 trifluoroacetate salt
• Empirical Formula (Hill Notation): C₃₁H₃₂N₈O₅ · xC₂HF₃O₂
• CAS Number: 1085412-37-8
• Molecular Weight: 596.64 (free base basis)
• MDL number: MFCD26142941
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825581
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC(C(F)(F)F)=O.O=C(NC1=CC(OCCN)=C(C=CC=C2)C2=N1)C3=CC(OCCN)=CC(C(NC4=NC(C=CC=C5)=C5C(OCCN)=C4)=O)=N3
• InChI: 1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)
• InChI key: SLFYRKZWSPFGQZ-UHFFFAOYSA-N

Description

Application

Pyridostatin trifluoroacetate salt has been used as a G-quadruplex (G4) stabilizer to study interactions between RNA G4 and ligand molecules.

Biochem/physiol Actions

Pyridostatin is a highly selective G-quadruplex interacting molecule. It retards the growth of human cancer cells by inducing replication/transcription dependent on DNA damage.

Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

Other Notes

Light sensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable