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LY-334370 hydrochloride hydrate

Name: LY-334370 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₂FN₃O · HCl · xH₂O

CAS Number:

199673-74-0

Molecular Weight:

387.88 (anhydrous basis)

MDL number:

MFCD11519957

UNSPSC Code:

12352202

PubChem Substance ID:

329825086

NACRES:

NA.77

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H₂O: ≥5 mg/mL (warmed)

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl.CN1CCC(CC1)c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23

InChI

1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H

InChI key

DGPDGAPZTPSHBL-UHFFFAOYSA-N

Application

LY-334370 hydrochloride hydrate may be used to study 5-HT 1F-mediated cell signaling.

Biochem/physiol Actions

LY-334370 hydrochloride is a selective 5-HT1F receptor agonist.

LY-334370 modulates the transmission in the mouse trigeminal system and inhibits the neuronal responses within rat Sp5C by inhibiting c-Fos activation. It shows efficacy in aborting migraine attacks.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.

Sandra A Filla et al.

Journal of medicinal chemistry, 46(14), 3060-3071 (2003-06-27)

Compound 1a (LY334370), a selective 5-HT(1F) receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extravasation model of migraine and demonstrated clinical efficacy for the acute treatment of migraine. Although 1a was greater than 100-fold selective over both

5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.

D D Mitsikostas et al.

Cephalalgia : an international journal of headache, 22(5), 384-394 (2002-07-12)

In order to investigate the c-fos response within the trigeminal nucleus caudalis (Sp5C) after noxious meningeal stimulation, capsaicin (0.25, 0.5, 1 and 5 nmol) was administered intracisternally in urethane (1 g/kg) and alpha-chloralose (20 mg/kg) anaesthetized male mice. Capsaicin induced

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