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Sigma-Aldrich

cAMP Dependent PKI Peptide

≥95% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):
C85H149N31O24
Molecular Weight:
1989.29
UNSPSC Code:
12352202
NACRES:
NA.32

product name

cAMP Dependent Protein Kinase Inhibitor PKI-tide,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥67%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Ile-Ala-Ala-Gly-Arg-Thr-Gly-Arg-Arg-Gln-Ala-Ile-His-Asp-Ile-Leu-Val-Ala-Ala

Application

IAAGRTGRRQAIHDILVAA is used as a cAMP-dependent protein kinase inhibitory peptide.

Biochem/physiol Actions

cAMP dependent protein kinase inhibitors are generally designed to target the synthesis and degradation of cAMP (cyclic adenosine monophophaphate), a second messenger.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design
Taylor SS, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1784(1), 16-26 (2008)
Barbara Wienen-Schmidt et al.
ChemMedChem, 16(1), 292-300 (2020-10-09)
In lead optimization, protein crystallography is an indispensable tool to analyze drug binding. Binding modes and non-covalent interaction inventories are essential to design follow-up synthesis candidates. Two protocols are commonly applied to produce protein-ligand complexes: cocrystallization and soaking. Because of

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