FGFR4 (fibroblast growth factor receptor 4) belongs to FGFR kinase family. In adult tissues, FGFR is expressed in a cell type-specific mode. It is located on chromosome 5q35.
The antibody detects endogenous level of total FGFR4 protein.
Immunogen
Peptide sequence around aa. 45-49 ( L-T-V-A-L), according to the protein NP_002002.3
Biochem/physiol Actions
Aberrations in FGFR4 results in neuroblastoma and altered receptor degradation. It acts as a predictive biomarker in oral and oropharyngeal squamous cell carcinoma. Suppressing FGFR4 may affect the biological characteristics in gastric cancer cells.
Features and Benefits
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Target description
Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Certificates of Analysis (COA)
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FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma
Koole K, et al.
Pathobiology (2015)
The role of genetic and epigenetic changes in pituitary tumorigenesis
Fukuoka H and Takahashi Y
Neurologia Medico-Chirurgica (2014)
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
Yu C, et al.
The Journal of Biological Chemistry (2000)
Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer
Ye Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2016)
A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation
Whittle SB, et al.
Journal of Pediatric Hematology (2016)
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