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SAB2500030

Sigma-Aldrich

Anti-Adenosine A2B Receptor antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ADORA2, Anti-ADORA2B, Anti-HGNC:264, Anti-Netrin-1 receptor

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADORA2B(136)

General description

ADORA2B (adenosine A2b receptor) is a G-protein coupled receptor. It is the most adenosine insensitive adenosine receptor. This gene is located on human chromosome 17p12-p11.2.

Immunogen

Peptide with sequence CQADVKSGNGQ from the C Terminus of the protein sequence according to NP_000667.1.

Biochem/physiol Actions

ADORA2B (adenosine A2b receptor) acts as a therapeutic target for cancer treatment. The tumor cells can use A2b receptor to induce progression. ADORA2B controls immune cell activity. It plays a major role in the transcriptional induction and protein stability of protein period 2 (Per2).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Eckle T, et al.
Nature Medicine, 18(5), 774?782-774?782 (2012)
Linya Wang et al.
PloS one, 19(6), e0301223-e0301223 (2024-06-05)
New immune checkpoints are emerging in a bid to improve response rates to immunotherapeutic drugs. The adenosine A2A receptor (A2AR) has been proposed as a target for immunotherapeutic development due to its participation in immunosuppression of the tumor microenvironment. Blockade
Role of adenosine A2b receptor overexpression in tumor progression.
Sepulveda C, et al.
Life Sciences, 166, 92-99 (2016)
Pharmacogenetics of asthma.
Fenech A and Hall IP
British Journal of Clinical Pharmacology, 53(1), 3-15 (2002)
The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism.
M?lck C, et al.
Cancer Letters, 383(1), 135-143 (2016)

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