PLA0259

Rabbit anti-RuvBL2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, 51-KD, CGI-46, ECP-51, ECP51, INO80 complex subunit J, INO80J, RVB2, Reptin 52, Reptin52, RuvB (E coli homolog)-like 2, RuvB-like 2 (E. coli), TAP54-beta, TIH2, TIP48, TIP49b, TIP60-associated protein 54-beta, erythrocyte cytosolic protein, repressing pontin 52, reptin, reptin52 protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• grade: Powered by Bethyl Laboratories, Inc.
• species reactivity: human, mouse
• technique(s): immunohistochemistry: 1:500- 1:2,000; immunoprecipitation (IP): 5-15 μg/mg; western blot: 1:2,000- 1:10,000
• accession no.: NP_006657.1
• UniProt accession no.: Q9Y230
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... RuvBL2(10856)

Description

General description

RuvB-like 2 (RUVBL2), a transcription factor, belongs to the AAA+ protein subfamily of conserved ATPases linked with diverse cellular functions. A distinctive domain II (DII) protrudes from one side of the hexamer and defines two separate faces of the ring in RUVBL2.

Immunogen

The epitope recognized by PLA0259 maps to a region between residue 1 and 50 of human RuvB-like 2 using the numbering given in entry NP_006657.1 (GeneID 10856).

Biochem/physiol Actions

RuvB-like 2 (RUVBL2) plays a regulatory role in the Fanconia anemia (FA) pathway, the assembly of the telomerase holoenzyme, and nonsense-mediated mRNA decay (NMD). It may play a role in tumorigenesis and cancer progression. Overexpression of the RUVBL2 protein is observed in hepatocellular carcinoma (HCC), renal cell carcinoma, colorectal cancer, gastric cancer, breast cancer, and salivary gland cancer. It can be used as a promising target for preventing and treating HCC.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

RuvB-like 2 (RuvBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities [taken from NCBI Entrez Gene (GeneID: 9400)].

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable