P9625

Phenazine methosulfate

powder, electron acceptor

• Synonym(s): 5-Methylphenazinium methyl sulfate, N-Methylphenazonium methyl sulfate, PMS
• Linear Formula: C₁₃H₁₁N₂ · CH₃SO₄
• CAS Number: 299-11-6
• Molecular Weight: 306.34
• Beilstein: 3898869
• EC Number: 206-072-1
• MDL number: MFCD00011923
• UNSPSC Code: 12352200
• PubChem Substance ID: 24899045
• NACRES: NA.77

Properties

• Product Name: Phenazine methosulfate,
• form: powder
• Quality Level: 200
• λ: 0.01 g/L in H₂O, 1 cm path
• UV absorption: λ: 387.5 nm A_max
• antibiotic activity spectrum: fungi
• Mode of action: DNA synthesis | interferes; cell membrane | interferes
• storage temp.: −20°C
• SMILES string: COS([O-])(=O)=O.C[n+]1c2ccccc2nc3ccccc13
• InChI: 1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1
• InChI key: RXGJTUSBYWCRBK-UHFFFAOYSA-M

Description

General description

Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.[1]

Application

Phenazine methosulfate is used with ascorbic acid to determine nitric oxide reductase activity.
Phenazine methosulfate has been used:

• as a component of succinate dehydrogenase enzyme substrate solution[2]
• to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability[3]
• as a component of complex II histochemistry media[4]

Biochem/physiol Actions

Phenazine m ethosulfate (PMS) acts as a good electron acceptor.[1] PMS is reduced non-enzymatically by (nicotinamide adenine dinucleotide) NADH and (nicotinamide adenine dinucleotide phosphate) NADPH.[5]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves