P1038
Poly(cytidylic-inosinic) acid potassium salt
random copolymer
Synonym(s):
Poly (C,I)
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Application
Poly(cytidylic-inosinic) acid potassium salt has been used:
- in pretreatment to understand Con A-induced hepatitis in mice
- in RNA extraction from hemolymph plasma for qPCR detection assay
- to induce inflammatory changes in liver
- as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells
Biochem/physiol Actions
Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).
Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.
Other Notes
Random copolymer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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