N8287
NSC 625987
≥97% (HPLC)
Synonym(s):
1,4-Dimethoxy-9-thio(10H)-acridone
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About This Item
Empirical Formula (Hill Notation):
C15H13NO2S
CAS Number:
Molecular Weight:
271.33
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
solubility
DMSO: 14 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccc(OC)c2C(=S)c3ccccc3Nc12
InChI
1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)
InChI key
KFAKESMKRPNZTM-UHFFFAOYSA-N
Biochem/physiol Actions
NSC 625987 is a selective, potent Cdk4/cyclin D1 inhibitor.
Caution
Air-sensitive
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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A Kubo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 5(12), 4279-4286 (2000-01-13)
Loss of p16 functional activity leading to disruption of the p16/cyclin-dependent kinase (CDK) 4:cyclin D/retinoblastoma pathway is the most common event in human tumorigenesis, suggesting that compounds with CDK4 kinase inhibitory activity may be useful to regulate cancer cell growth.
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