Skip to Content
Merck
All Photos(1)

Documents

M9261

Sigma-Aldrich

5-Methoxyuridine

Synonym(s):

mo(5)U

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C10H14N2O7
CAS Number:
Molecular Weight:
274.23
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:

Assay

≥98% (HPLC)
≥99% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

COC1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)NC1=O

InChI

1S/C10H14N2O7/c1-18-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)19-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1

InChI key

ZXIATBNUWJBBGT-JXOAFFINSA-N

Looking for similar products? Visit Product Comparison Guide

Application

5-Methoxyuridine is a constituent of the first position of the anticodon of select bacterial tRNA molecules. 5-Methoxyuridine may be used to study the effects of substitutions on the codon reading efficiencies of tRNAs.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Rebuma Firdessa-Fite et al.
Molecular therapy. Methods & clinical development, 16, 50-62 (2019-12-25)
The efficacy of antigen-specific immunotherapy relies heavily on efficient antigen delivery to antigen-presenting cells and engagement of as many disease-relevant T cells as possible in various lymphoid tissues, which are challenging to achieve. Here, we compared two approaches to deliver mRNA
K Murao et al.
Nucleic acids research, 3(10), 2851-2860 (1976-10-01)
The sequences of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis W 168 were N-G-C, N-G-U, and N-A-C, respectively. A new minor constituent, N, occupied the first position of the anticodon of each tRNA. N was indentified as
5-Methoxyuridine, a new modified constituent in tRNAs of Bacillaceae.
M Albani et al.
FEBS letters, 70(1), 37-42 (1976-11-01)
J Matsugi et al.
Biochimica et biophysica acta, 1130(3), 333-335 (1992-04-06)
Three B. subitilis serine tRNAs were sequenced including modified nucleosides. All the serine tRNAs contained 1-methyl-adenosine in the D-loop. As other characteristic modified nucleosides, 5-methoxyuridine was found in the first letter of the anticodon in the tRNA(UGA).
Yuko Yamada et al.
Biochimica et biophysica acta, 1728(3), 143-149 (2005-04-19)
In Bacillus subtilis, four codons, CCU, CCC, CCA, and CCG, are used for proline. There exists, however, only one proline-specific tRNA having the anticodon mo(5)UGG. Here, we found that this tRNA(Pro)(mo(5)UGG) can read not only the codons CCA, CCG and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service