An efficient strategy for the control of the chemoselectivity in Dieckmann ring closures leading to tetramic acids derived from serine and α-methyl serine is reported, and this provides pathways to diversely substituted systems from a common starting material.
An approach to enantioselective activation of N-benzoyl-alpha-methylserine with chiral N-triazinylammonium chloride.
Beata Kolesińska et al.
Acta poloniae pharmaceutica, 63(5), 426-429 (2007-03-16)
Biochemical and biophysical research communications, 340(3), 823-828 (2005-12-29)
In many complexes formed by serine proteinases and their inhibitors, the hydroxyl group provided by water molecule or by the inhibitor Ser residue is located close to the inhibitor P1-P1' reactive site. In order to investigate the role of this
Chemical communications (Cambridge, England), 47(18), 5319-5321 (2011-04-01)
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the
Journal of mental deficiency research, 26 (Pt 2), 107-110 (1982-06-01)
An inherited defect in the glycine cleavage enzyme results in the condition of neonatal glycine encephalopathy which has not responded to the current innovative methods of therapy. A re-examination of the enzyme structure and metabolic pathways, leads us to recommend
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