M5191
Anti-Matrix Metalloproteinase-28, Propeptide Region antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-Epilysin, Anti-MMP-28
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100 μG
€478.00
€478.00
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100 μG
€478.00
About This Item
€478.00
Please contact Customer Service for Availability
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MMP28(79148)
General description
Matrix metalloproteinase-28 (MMP-28) is expressed in normal tissues like the epidermis of the skin, brain, lungs and intestine. It possesses an activation sequence and a pro-domain. The gene encoding it is localized on human chromosome 17q11.2 and has eight exons.
Specificity
By immunoblotting against the reduced protein, the antibody identifies bands at 62 kDa and 58 kDa, as well as breakdown products at 50 kDa, 48 kDa, and 46 kDa. At higher antibody concentrations, the antibody also detects a 70 kDa band in rat and mouse tissues.
Immunogen
synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-28.
Biochem/physiol Actions
Matrix metalloproteinase-28 (MMP-28) may have a role in modulating matrix composition. It is an endopeptidase which degrades casein and mediates epithelial to mesenchymal transition. MMP-28 aids in progression of tumors and is overexpressed in gastric carcinomas.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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mRNA expression of MMP-28 (Epilysin) in gingival tissues of chronic and aggressive periodontitis patients: a reverse transcriptase PCR study.
Padmavati P
Disease Markers, 35(2), 113-118 (2013)
MMP28 and macrophage polarization: orchestrating the attack of the mac.
Ye Gan et al.
Journal of leukocyte biology, 95(1), 1-3 (2014-01-05)
Helen E Gruber et al.
Arthritis research & therapy, 11(6), R184-R184 (2009-12-17)
The regulation and elevation in expression of the catabolic matrix metalloproteinases (MMPs) is of high importance in the human intervertebral disc since upregulation of these matrix-degrading enzymes results in matrix destruction associated with disc degeneration. MMP28 (epilysin) is a newly
Tuomas J Heiskanen et al.
Matrix biology : journal of the International Society for Matrix Biology, 28(2), 74-83 (2009-04-22)
Epilysin (MMP-28) is a conserved member of the matrix metalloproteinase (MMP) family. It is expressed in various normal tissues, and induced in wounds and in developing and regenerating nerves. Epilysin induces TGF-beta mediated epithelial to mesenchymal transition, but its other
Marina Klawitter et al.
Journal of negative results in biomedicine, 10, 9-9 (2011-08-02)
MMP28 (epilysin) is a recently discovered member of the MMP (matrix metalloproteinase) family that is, amongst others, expressed in osteoarthritic cartilage and intervertebral disc (IVD) tissue. In this study the hypothesis that increased expression of MMP28 correlates with higher grades
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