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M4758

Sigma-Aldrich

(±)-6-Methyl-5,6,7,8-tetrahydropterine dihydrochloride

~95% (TLC)

Synonym(s):

6-MPH4, DL-2-Amino-4-hydroxy-6-methyl-5,6,7,8-tetrahydropteridine dihydrochloride

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50 MG
€245.00
100 MG
€296.00

€245.00

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50 MG
€245.00
100 MG
€296.00

About This Item

Empirical Formula (Hill Notation):
C7H11N5O · 2HCl
CAS Number:
69113-63-9
Molecular Weight:
254.12
Beilstein:
5648114
MDL number:
MFCD00058175
UNSPSC Code:
12352204
PubChem Substance ID:
24896941
NACRES:
NA.51

€245.00

Please contact Customer Service for Availability

Assay

~95% (TLC)

Quality Level

200

storage temp.

−20°C

SMILES string

Cl.Cl.CC1CNc2nc(N)nc(O)c2N1

InChI

1S/C7H11N5O.2ClH/c1-3-2-9-5-4(10-3)6(13)12-7(8)11-5;;/h3,10H,2H2,1H3,(H4,8,9,11,12,13);2*1H

InChI key

MKQLORLCFAZASZ-UHFFFAOYSA-N

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Application

6-MPH4 is used to study mechanisms of nitric oxide (NO) synthase and free radical induced L-DOPA release from striatal tissue.

Biochem/physiol Actions

Synthetic cofactor for tyrosine hydrolase; also cofactor for phenylalanine and tryptophan hydroxylases; less activity than the natural cofactor, BH4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000421229
0000421229
0000365357
0000342948
0000365357

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L-Tryptophan reagent grade, ≥98% (HPLC)

Sigma-Aldrich

T0254

L-Tryptophan

M Bauer et al.
Journal of neurochemistry, 82(5), 1300-1310 (2002-10-03)
Glial cell line-derived neurotrophic factor (GDNF) protects dopaminergic neurones against toxic and physical damage. In addition, GDNF promotes differentiation and structural integrity of dopaminergic neurones. Here we show that GDNF can support the function of primary dopaminergic neurones by triggering
Elizabeth A Gaskell et al.
PloS one, 4(3), e4801-e4801 (2009-03-12)
The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase; that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for tyrosine. Thus the enzymes catabolize phenylalanine to
P Abreu-González et al.
European journal of pharmacology, 541(1-2), 33-37 (2006-06-06)
In the present study we have analyzed the effect of tetrahydrobiopterin (BH4) essential cofactor for tyrosine hydroxylase and nitric oxide synthase, on the 3,4-dihydroxyphenylalanine (L-DOPA) release from in vitro incubated striatal tissue. dl-6-methyl-5,6,7,8 tetrahydropterine (6-MPH4)-stimulated L-DOPA release in a concentration-dependent
J R Bostwick et al.
Analytical biochemistry, 192(1), 125-130 (1991-01-01)
A radiometric assay for tyrosine hydroxylase employing a coupled nonenzymatic decarboxylation of L-[14C]Dopa formed from L-[14C]tyrosine has been adapted for performance in a 96 microwell culture plate. The method uses an easily manufactured plate holder to compress blotting paper impregnated
M Naoi et al.
Journal of chromatography, 427(2), 229-238 (1988-06-03)
A simple assay procedure for tyrosine hydroxylase activity in crude tissue samples was devised that requires minimal sample preparation and use of high-performance liquid chromatography with coulometric electrochemical detection. After incubation of enzyme samples, such as human brain homogenates or
View All Related Papers

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