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L6543

Sigma-Aldrich

Lacto-N-neo-tetraose

synthetic, ≥85% (HPLC)

Synonym(s):

β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc, LNnT

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About This Item

Empirical Formula (Hill Notation):
C26H45NO21
CAS Number:
13007-32-4
Molecular Weight:
707.63
MDL number:
MFCD00467190
UNSPSC Code:
12352201
PubChem Substance ID:
24896438
NACRES:
NA.25

biological source

synthetic

Assay

≥85% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

CC(=O)NC1C(O)C(OC2OC(CO)C(O)C(O)C2O)C(CO)OC1OC3C(O)C(CO)OC(OC(C(O)CO)C(O)C(O)C=O)C3O

InChI

1S/C26H45NO21/c1-7(33)27-13-17(39)22(47-25-19(41)18(40)15(37)10(4-30)43-25)12(6-32)45-24(13)48-23-16(38)11(5-31)44-26(20(23)42)46-21(9(35)3-29)14(36)8(34)2-28/h2,8-26,29-32,34-42H,3-6H2,1H3,(H,27,33)

InChI key

RBMYDHMFFAVMMM-UHFFFAOYSA-N

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBM9050V
SLBH0057V
SLBF3582V
SLBF3582
SLBB8736

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Behrouz Farhadihosseinabadi et al.
Scientific reports, 10(1), 997-997 (2020-01-24)
Lacto-n-neotatraose (LNnT) oligosaccharide shows properties such as anti-inflammatory, type 2 immune response induction, induced angiogenesis, and anti-bacterial effects. Here, we hypothesized that the application of LnNT in the skin full-thickness wound can accelerate the healing process through its anti-inflammatory effect
Laetitia Renaudie et al.
Carbohydrate research, 339(3), 693-698 (2004-03-12)
The lacto-N-neotetraose tetrasaccharide was synthesized on a new dendrimeric support, based on polyethylene glycol. Starting from 1-thio-beta-D-lactose, the trisaccharide (2-acetamido-2-deoxy-beta-D-glucopyranosyl)-(1-->3)-O-beta-D-galactopyranosyl-(1-->4)-1-thio-beta-D-glucopyranose was obtained using Neisseria meningitidis beta-(1-->3)-N-acetylglucosaminyltransferase according to a soluble synthesis approach, bound on the support and galactosylated using the
Julie Elisabeth Heggelund et al.
International journal of molecular sciences, 20(3) (2019-02-10)
Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile
Liana Steeghs et al.
Cellular microbiology, 8(2), 316-325 (2006-01-31)
Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique
Erina Yoshida et al.
Glycobiology, 22(3), 361-368 (2011-09-20)
The breast-fed infant intestine is often colonized by particular bifidobacteria, and human milk oligosaccharides (HMOs) are considered to be bifidogenic. Recent studies showed that Bifidobacterium longum subsp. infantis can grow on HMOs as the sole carbon source. This ability has
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