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H4884

Sigma-Aldrich

Hippuryl-His-Leu acetate salt

Synonym(s):

N-Benzoyl-Gly-His-Leu

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About This Item

Empirical Formula (Hill Notation):
C21H27N5O5
CAS Number:
103404-54-2
Molecular Weight:
429.47
UNSPSC Code:
12352200
PubChem Substance ID:
329815212
NACRES:
NA.32

Assay

≥98% (HPLC)

form

powder

solubility

acetic acid: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.C2H4O2/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;1-2(3)4/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H3,(H,3,4)/t16-,17-;/m0./s1

InChI key

NSEVQQKNHZCIKL-QJHJCNPRSA-N

Gene Information

human ... ACE(1636) , ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421) , ACE2(70008) , ACE3(498012)

Amino Acid Sequence

NBz-Gly-His-Leu

Biochem/physiol Actions

Substrate for angiotensin converting enzyme.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Mammalian Genome null
Lucas Actis-Goretta et al.
FEBS letters, 555(3), 597-600 (2003-12-17)
It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin. The inhibition by flavan-3-ols and procyanidins was competitive
Neha Chaudhary et al.
Journal of food science and technology, 57(4), 1371-1381 (2020-03-18)
Controlled release of Emblicanin rich water soluble extract of Emblica officinalis (EEO) from the inner phase of water-in-oil-in-water type double emulsion (DE), during in vitro digestion and phagocytosis was investigated. It was observed that release of EEO (measured as total polyphenols
Jelena Kamilic et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 20(3), 170-179 (2009-03-04)
In humans, the insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene accounts for half of the variance in plasma ACE activity. The deletion allele is associated with high plasma ACE activity, cardiovascular disease, and renal disease. In rat, a
Matthew L Hemming et al.
The Journal of biological chemistry, 280(45), 37644-37650 (2005-09-13)
Human genetic data have associated angiotensin-converting enzyme (ACE) with Alzheimer disease (AD), and purified ACE has been reported to cleave synthetic amyloid beta-protein (Abeta) in vitro. Whether deficiency in ACE activity, arising from genetic alteration or pharmacological inhibition, can decrease
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