H1666

Anti-HOXC4 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Homeobox 3E, Anti-Homeobox C4, Anti-Hox-3E CP19
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~40 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 2.5-5 μg/mL using lysates of HEK-293T cells over-expressing human HOXC4; indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde-fixed HEK-293T cells over-expressing human HOXC4; western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over-expressing human HOXC4
• UniProt accession no.: P09017
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... HOXC4(3221) ; mouse ... Hoxc4(15423) ; rat ... Hoxc4(24459)

Description

General description

The Homeobox C4 (HOXC4) is located on the human chromosome at 12q13.13.

Specificity

Anti-HOXC4 (N-terminal) recognizes human HOXC4 (also known as Hox-3E and CP19).

Application

Anti-HOXC4 (N-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Homeobox C4 (HOXC4) transcription factor/protein stimulates the action of activation-induced cytosine deaminase (AID). The HOXC4 gene is upregulated due to the estrogen-estrogen receptor complexes. HOXC4 gene is expressed in the proliferating lymphocytes of B-, T- and natural killer (NK) cell lineage. This gene expression is elevated with the progression of lymphoid differentiation.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable