Heparin Cofactor II (HCII) is a member of the serpin superfamily and acts as a serine protease inhibitor. It rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. However, it should be noted that Heparin Cofactor II itself is not a proper anticoagulant. When used alone, it will not prevent blood from coagulating. For anticoagulant purposes, substances such as Heparin sodium salt, EDTA, or Sodium Citrate are commonly used in research and clinical laboratories.
H0417
Heparin Cofactor II from human plasma
aqueous glycerol solution, ≥90% (SDS-PAGE)
Synonym(s):
HCF2, HCII, SERPIND1
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100 μG
€645.00
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100 μG
€645.00
About This Item
Recommended Products
biological source
human plasma
Quality Level
Assay
≥90% (SDS-PAGE)
form
aqueous glycerol solution
mol wt
~66 kDa
~66 kDa
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... SERPIND1(3053)
Biochem/physiol Actions
Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.
Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.
Unit Definition
HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.
Physical form
50% aqueous glycerol solution (vol/vol)
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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