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F5900

Sigma-Aldrich

Monoclonal Anti-Interleukin-2−Carboxyfluorescein antibody produced in mouse

clone 5334, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Monoclonal Anti-Interleukin-2, Monoclonal Anti-IL-2

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

carboxyfluorescein conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5334, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG1

UniProt accession no.

P60568

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... IL2(3558)

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General description

Interleukin-2 (IL-2) also refers as T Cell Growth Factor is a cytokine produced by certain subsets of T lymphocytes. It plays various functions like inducing interferon γ and B cell growth factor secretion as well as affecting the activation and proliferation of NK cells. It also has a vital role in modulating the expression of the IL-2 receptor and can facilitate B cell growth and differentiation. Monoclonal anti-Interleukin-2−Carboxyfluorescein antibody reacts specifically with human IL-2.

Specificity

The conjugates will identify and quantitate cells containing intracellular forms of human IL-2 by flow cytometry.

Immunogen

recombinant human IL-2

Application

Monoclonal anti-Interleukin-2−Carboxyfluorescein antibody can be used in flow cytometry assays for identifying intracytoplasmic cytokines and for enumerating cytokine producing cells present in a mixed population.

Physical form

Solution in phosphate buffered saline containing 0.1% sodium azide.

Preparation Note

Purified antibody is conjugated to carboxyfluorescein.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D A Morgan et al.
Science (New York, N.Y.), 193(4257), 1007-1008 (1976-09-10)
Selective growth of T lymphocytes occurred when unfractionated normal human bone marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-stimulated normal human lymphocytes (Ly-CM). Cultures of up to 90 percent T cells have been maintained for more than 9
T A Waldmann et al.
The Journal of experimental medicine, 160(5), 1450-1466 (1984-11-01)
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2. Resting normal B cells and unselected B cell lines established from normal individuals were Tac antigen negative.
K A Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(3), 864-868 (1985-02-01)
The cell surface density of high-affinity membrane receptors for the T-lymphocytotrophic hormone interleukin 2 (IL-2) determines the rate of T-cell-cycle progression. Since 10-fold greater numbers of IL-2 receptor molecules were found by using a radiolabeled monoclonal antibody reactive with IL-2

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