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E8512

Sigma-Aldrich

Ethylmorphine

Synonym(s):

Morphine 3-ethyl ether

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About This Item

Empirical Formula (Hill Notation):
C19H23NO3
CAS Number:
76-58-4
Molecular Weight:
313.39
EC Number:
200-970-7
MDL number:
MFCD00083327
UNSPSC Code:
12352200
PubChem Substance ID:
24894676
NACRES:
NA.77

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

storage temp.

2-8°C

SMILES string

CCOc1ccc2C[C@@H]3C4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

InChI

1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1

InChI key

OGDVEMNWJVYAJL-LEPYJNQMSA-N

Biochem/physiol Actions

Narcotic analgesic; antitussive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H336

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
049K4008
107K4116
077K4072
037K4074
037K4011

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U D Kuhn et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 50(4-6), 484-490 (1998-10-23)
To investigate whether or not there is a beneficial effect of diltiazem (D) on cyclosporine A (CsA) nephrotoxicity, renal function, CsA blood levels, and effects of CsA on biotransformation in the liver and on lipid peroxidation were characterized in rats.
Arne Helland et al.
Journal of forensic sciences, 55(2), 551-553 (2010-02-18)
Ethylmorphine, an opiate that is partially metabolized to morphine, is a common ingredient in antitussive preparations. We present a case where a 10-month-old boy was administered ethylmorphine in the evening and found dead in bed the following morning. Postmortem toxicological
C Calléja et al.
International journal for parasitology, 30(8), 953-958 (2000-08-06)
The activity of drug-metabolising enzymes was compared in liver and kidneys of adult sheep given single or two-fold fluke infection. Fascioliasis was induced by oral administration of 200 metacercariae of Fasciola hepatica to female sheep either 10 or 20 weeks
Aliaa Nabil ElMeshad et al.
AAPS PharmSciTech, 21(7), 244-244 (2020-08-29)
Ethylmorphine hydrochloride (EtM) is a derivative of morphine used as analgesic to treat severe pain in case of cancer and bone injury. This study aimed to formulate and evaluate core in cup tablets containing 2 doses of EtM, the cup
W A Daniel et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 15(1), 103-110 (2004-12-02)
The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2D measured as a rate of ethylmorphine O-deethylation. The reaction was studied in control liver microsomes in the presence
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