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E131

Sigma-Aldrich

Ergocornine

>95%, solid

Synonym(s):

12′-Hydroxy-2′,5′-α-bis(1-methyl-ethyl)ergotaman-3′,6′,18-trione

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About This Item

Empirical Formula (Hill Notation):
C31H39N5O5
CAS Number:
564-36-3
Molecular Weight:
561.67
EC Number:
209-272-7
MDL number:
MFCD00274574
UNSPSC Code:
12352200
PubChem Substance ID:
24894401

Assay

>95%

form

solid

optical activity

[α]/D −105.6°, c = 0.85 in pyridine(lit.)

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.4 mg/mL
ethanol: 1.02 mg/mL
DMSO: 6.5 mg/mL
H2O: insoluble

SMILES string

[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@]5(O[C@]6(O)N([C@@H](C(C)C)C(=O)N7CCC[C@@]67[H])C5=O)C(C)C)c34

InChI

1S/C31H39N5O5/c1-16(2)26-28(38)35-11-7-10-24(35)31(40)36(26)29(39)30(41-31,17(3)4)33-27(37)19-12-21-20-8-6-9-22-25(20)18(14-32-22)13-23(21)34(5)15-19/h6,8-9,12,14,16-17,19,23-24,26,32,40H,7,10-11,13,15H2,1-5H3,(H,33,37)/t19-,23-,24+,26+,30-,31+/m1/s1

InChI key

UJYGDMFEEDNVBF-OGGGUQDZSA-N

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Biochem/physiol Actions

Dopamine receptor agonist; ergot alkaloid.

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Ergot drugs suppress plasma prolactin and lactation but not aggression in parturient mice.
M Mann et al.
Hormones and behavior, 14(4), 319-328 (1980-12-01)
J C Young
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 16(4), 381-393 (1981-01-01)
The total alkaloid content and individual alkaloid composition were determined by colorimetry and high performance liquid chromatography, respectively, for Canadian wheat ergot sclerotia. The total alkaloid content was highly variable between individual sclerotia from the same or different sources and
L C Minasian-Batmanian et al.
British journal of cancer, 43(6), 832-841 (1981-06-01)
The effects of hormone and drug treatments on plasma prolactin (PRL) levels and mammary tumour growth were investigated in rats bearing continuously growing DMBA-induced mammary tumours that responded to bilateral adreno-ovariectomy (Ax + Ox), Oestrogen (E2) administration increased both plasma
H I Siegel et al.
Neuroscience and biobehavioral reviews, 4(1), 17-26 (1980-01-01)
This review covers a description of the maternal behavior cycle in the hamster and relationships between the endocrine system and prepartum changes in activity, aggression, sexual receptivity, and maternal care. Postpartum maternal behavior consists of the mother's "normal" cannibalism of
Madeleine Gross et al.
Journal of AOAC International, 101(3), 618-626 (2017-10-02)
Four sets of polyclonal antibodies against ergot alkaloids ergometrine, ergotamine, α-ergocryptine, and ergocornine were produced and characterized in a competitive direct or indirect enzyme immunoassay (EIA). Standard curve LODs were 0.03 ng/mL (ergometrine EIA) to 2.0 ng/mL (ergocornine EIA). Three
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