C8912

Cocaine free base

• Synonym(s): Ecgonine methyl ester benzoate
• Empirical Formula (Hill Notation): C₁₇H₂₁NO₄
• CAS Number: 50-36-2
• Molecular Weight: 303.35
• EC Number: 200-032-7
• MDL number: MFCD00056906
• UNSPSC Code: 12352200
• PubChem Substance ID: 24893116
• NACRES: NA.77

Properties

• form: powder
• drug control: USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
• application(s): forensics and toxicology
• SMILES string: [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c3ccccc3)C(=O)OC)N2C
• InChI: 1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
• InChI key: ZPUCINDJVBIVPJ-LJISPDSOSA-N
• Gene Information: human ... DRD3(1814) , KCNH1(3756) , KCNH2(3757) , SCN10A(6336) , SCN11A(11280) , SCN5A(6331) , SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532) ; mouse ... Slc6a2(20538) ; rat ... Chrm1(25229) , Slc6a3(24898) , Slc6a4(25553)

Description

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 + H330,H336,H361d
• Precautionary Statements: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves