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B9688

Sigma-Aldrich

Pizotifen

≥98% (HPLC)

Synonym(s):

Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine

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10 MG
€86.70
50 MG
€336.00

€86.70

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10 MG
€86.70
50 MG
€336.00

About This Item

Empirical Formula (Hill Notation):
C19H21NS
CAS Number:
15574-96-6
Molecular Weight:
295.44
EC Number:
239-632-9
MDL number:
MFCD00864192
UNSPSC Code:
12352200
PubChem Substance ID:
329773323
NACRES:
NA.77

€86.70

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Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥8 mg/mL

originator

Novartis

storage temp.

room temp

SMILES string

CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24

InChI

1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

InChI key

FIADGNVRKBPQEU-UHFFFAOYSA-N

Biochem/physiol Actions

Pizotifen is a Serotonin antagonist used for prophylaxis of migraine
Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000416709
0000416710
0000416710
0000416709
041M4735V

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Joy A Weydert et al.
Pediatrics, 111(1), e1-11 (2003-01-02)
To conduct a systematic review of evaluated treatments for recurrent abdominal pain (RAP) in children. Online bibliographic databases were searched for the terms "recurrent abdominal pain," "functional abdominal pain," "children," or "alternative therapies" in articles classified as randomized controlled trials.
Prophylaxis of migraine headache.
Tamara Pringsheim et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 182(7), E269-E276 (2010-02-18)
Do pizotifen or propranolol reduce the frequency of migraine headache?
N Barnes et al.
Archives of disease in childhood, 89(7), 684-685 (2004-06-24)
Charles Kwaku Benneh et al.
Journal of ethnopharmacology, 207, 129-145 (2017-06-25)
Maerua angolensis DC (Capparaceae) has been employed in the management of several central nervous system (CNS) disorders including anxiety. This study evaluated the anxiolytic effects of the petroleum ether/ethyl acetate fraction stem bark extract and its possible mechanism(s) using zebrafish
A Huertas-Ceballos et al.
The Cochrane database of systematic reviews, (1)(1), CD003017-CD003017 (2008-02-07)
Between 4% and 25% of school-age children complain of recurrent abdominal pain (RAP) of sufficient severity to interfere with daily activities. For the majority no organic cause for their pain can be found on physical examination or investigation and although
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