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Y0000370

Risperidone for system suitability

Name: Risperidone for system suitability
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Risperidone, R 64,766

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₇FN₄O₂

CAS Number:

106266-06-2

Molecular Weight:

410.48

MDL number:

MFCD00274576

UNSPSC Code:

41116107

PubChem Substance ID:

329830925

NACRES:

NA.24

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USP

1604676

Risperidone Related Compounds Mixture

R1000600

Risperidone

Sigma-Aldrich

SML3059

Lacosamide

Sigma-Aldrich

5.08508

Zonisamide

Y0001276

Risperidone impurity K

Supelco

PHR1631

Risperidone

USP

1151855

Curcumin

M1825000

Metoclopramide hydrochloride

I0750000

Isopropyl tetradecanoate

S0460000

Sertaconazole nitrate

grade

pharmaceutical primary standard

API family

risperidone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1

InChI

1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

InChI key

RAPZEAPATHNIPO-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813) , HTR2A(3356) , HTR2C(3358)

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General description

Risperidone is a new central 5-hydroxytryptamine2 and dopamine D2 antagonist. It is used to treat agitation, aggression,and psychosis caused during demnetia. It is a neuroleptic drug. It is also an atypical antipsychotic drug which is used for treating schizophrenia.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Risperidone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1604676

Y0001276

Risperidone impurity K, European Pharmacopoeia (EP) Reference Standard

1604756

PHR1631

Risperidone, Pharmaceutical Secondary Standard; Certified Reference Material

BP1137

Risperidone, British Pharmacopoeia (BP) Reference Standard

BP1158

Risperidone impurity standard, British Pharmacopoeia (BP) Reference Standard

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Effects of eight weeks of atypical antipsychotic treatment on middle frontal thickness in drug-naïve first-episode psychosis patients.

Vina M Goghari et al.

Schizophrenia research, 149(1-3), 149-155 (2013-07-09)

Atypical antipsychotic medications generally maintain or increase gray matter amount and functioning. First-episode psychosis patients have lower gray matter volume in the middle frontal gyrus, as well as worse performance on spatial working memory tasks compared to controls. This study

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.

W Victor R Vieweg et al.

Psychopharmacology, 228(4), 515-524 (2013-07-03)

A recent publication asserted that even low-dose risperidone may induce corrected QT (QTc) interval prolongation up to 500 ms without drug-induced IKr blockade. We seek to better understand the complexity of any link between risperidone-induced/associated QTc interval prolongation and torsade de

Risperidone long-acting injection as monotherapy and adjunctive therapy in the maintenance treatment of bipolar I disorder.

Andrea Fagiolini et al.

Expert opinion on pharmacotherapy, 11(10), 1727-1740 (2010-05-22)

It is very rare for patients with bipolar disorder to have a single episode of mania or depression over a lifetime and the vast majority of these individuals need long-term prophylactic/maintenance treatment. However, treatment nonadherence is a major issue for

Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.

Jérôme A J Becker et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2049-2060 (2014-03-13)

The etiology of Autism Spectrum Disorders (ASDs) remains largely unknown. Identifying vulnerability genes for autism represents a major challenge in the field and allows the development of animal models for translational research. Mice lacking the mu opioid receptor gene (Oprm1(-/-))

Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study.

Yvonne Freund-Levi et al.

Dementia and geriatric cognitive disorders, 38(3-4), 234-244 (2014-06-28)

To examine the effects of galantamine and risperidone on agitation in patients with dementia. A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized

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