SBR00026

Ligstroside

Nitric oxide inhibitor, ≥95%

• Synonym(s): (-)-ligstroside, Ligustroside
• Empirical Formula (Hill Notation): C₂₅H₃₂O₁₂
• CAS Number: 35897-92-8
• Molecular Weight: 524.51
• UNSPSC Code: 12352200
• NACRES: NA.25

Properties

• biological source: plant
• Quality Level: 100
• Assay: ≥95%
• form: lyophilized powder
• mol wt: 524.51
• solubility: DMSO: ≥10 mg/mL (19 mM); methanol: ≥10 mg/mL
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• InChI: 1S/C25H32O12/c1-3-15-16(10-19(28)34-9-8-13-4-6-14(27)7-5-13)17(23(32)33-2)12-35-24(15)37-25-22(31)21(30)20(29)18(11-26)36-25/h3-7,12,16,18,20-22,24-27,29-31H,8-11H2,1-2H3/b15-3+/t16-,18+,20+,21-,22+,24-,25-/m0/s1
• InChI key: GMQXOLRKJQWPNB-MVVLSVRYSA-N

Description

General description

Ligstroside, also known as ligusroside, is a secoiridoid glycoside, a bioactive natural compound commonly derived from plants like Ligustrum lucidum, Jasminum officinale, and Osmanthus heterophyllus. Existing research suggests that this metabolite functions as an nitric oxide inhibitor and may exhibit diverse biological activities, including anti-neoplastic, antioxidant, antiviral, and anti-inflammatory properties.

Application

Ligstroside is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE₂ (prostaglandin E₂) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB₂ (thromboxane B₂) levels in human platelets (IC50 = 122.63 μM). Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells.^, Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM).

Features and Benefits

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Storage and Stability

Hygroscopic; store in dry place with desiccant

Other Notes

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable