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PHR1154

Supelco

Tributyl citrate

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

Empirical Formula (Hill Notation):
C18H32O7
CAS Number:
77-94-1
Molecular Weight:
360.44
Beilstein:
1806072
EC Number:
201-071-2
MDL number:
MFCD00027217
UNSPSC Code:
41116107
PubChem Substance ID:
329823172
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1680608

API family

tributyl acetylcitrate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.445

density

1.043 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCOC(=O)CC(O)(CC(=O)OCCCC)C(=O)OCCCC

InChI

1S/C18H32O7/c1-4-7-10-23-15(19)13-18(22,17(21)25-12-9-6-3)14-16(20)24-11-8-5-2/h22H,4-14H2,1-3H3

InChI key

ZFOZVQLOBQUTQQ-UHFFFAOYSA-N

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General description

Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.[1]


Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8989 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Handbook of Pharmaceutical Excipients, 1 (2006)
Eva Roblegg et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 79(3), 635-645 (2011-08-02)
The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic excipient. The matrix carrier was hot melt extruded and pelletized with a hot-strand cutter in a one step continuous process.
Bernadette Pretzl et al.
Journal of clinical periodontology, 36(4), 349-356 (2009-05-12)
Evaluation of the 10-year results after GTR-therapy of infrabony defects using two bioabsorbable barriers in a randomized-controlled clinical trial. In 15 patients with periodontitis, 15 pairs of infrabony defects were treated. For each patient, one defect received a polydioxanon (test:
W Korsatko et al.
Die Pharmazie, 38(9), 608-611 (1983-09-01)
Matrix type tablets containing 7-hydroxyethyltheophylline, L-noradrenaline and L-isoproterenol were coated with Eudragit RS 100 film containing different concentrations of 1,2-propyleneglycol (PG) and tributylcitrate (TBC) as hydrophylic and lipophilic softeners, respectively, to effect a controlled liberation of the substances. In-vitro and
D Hutchings et al.
Pharmaceutical research, 11(10), 1474-1478 (1994-10-01)
The influence of curing time and curing temperature for a commercially available ethylcellulose latex coating dispersion (Aquacoat) were evaluated using response surface methodology. Levels for the factor curing time ranged from 30 to 300 minutes while levels for curing temperature
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